Ilzira Minigalieva
The Ekaterinburg Medical Research Center, Russia
Title: Some discrepancies between a standard practice of cumulated health risks assessment and the based-on-experiment theory of metal nanoparticles combined toxicity.
Biography
Biography: Ilzira Minigalieva
Abstract
Assessment of cumulative health risks associated with the combined effects of two or more metal oxide nanoparticles on the organism of workers widely observed in several industries (e..g. metallurgy, arc-welding, laser processing of metals) should be theoretically and experimentally based on the toxicology of mixtures. Meanwhile there is no full match between the said assessment and this scientific basis, some of the contradictions between them being fundamental. This state of things is caused not only by simplifications characteristic of the generally recognized risk assessment methodology but also by the extreme complexity and some intrinsic inconsistency of the theory of combined toxicity, the most essential issues of which are considered by us on the basis of literary and, mostly, our own data. In particular, we studied by acute intratracheal and subchronic intraperitoneal experiments on rats and by the mathematical modeling of general patterns and some specific peculiarities of (NiO + Mn3O4), (CuO+ ZnO), (CuO+ PbO), (ZnO+PbO), (CuO+ ZnO + PbO), (TiO2 + Al2O3), (TiO2 +SiO2), (Al2O3 + SiO2), and (TiO2 + Al2O3 + SiO2) nanoparticle combined action. Feasible approaches to solving practically important problems associated with the above-mentioned discrepancies are proposed.